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Clinical cases

A RARE CASE OF UNICENTRIC PLASMA CELL TYPE CASTLEMANíS DISEASE IN THE MEDIASTINUM

Claudiu Nistor*, Mihnea Davidescu*, Adrian Ciuche*, Corina Bluoss*, Natalia Motaş*, Cezar Motaş*, Teodor Horvat*
A RARE CASE OF UNICENTRIC PLASMA CELL TYPE CASTLEMANíS DISEASE IN THE MEDIASTINUM

ABSTRACT

Castleman disease is a very rare (and thus little-known) lymphoproliferative disorder characterized by lymph node follicular hyperplasia with abnormal interfollicular vascular growth. It can be classified into unicentric and multicentric variants according to its localization, and into three histological types: hyaline-vascular, plasma cell and mixed.

We describe the case of a 51 year-old woman who presented with precordial chest pain. Chest X-Ray and computed tomography (CT) raised the suspicion of an aortic aneurysm, and the patient was sent to the Interventional Cardiology Clinic at the Military Emergency Clinical Center for Cardiovascular Diseases (CCUBCVA), where the diagnosis of mediastinal tumor was made by ultrasonography, coronarography and CT. The patient was transferred to our clinic, where a diagnostic mediastinoscopy proved histolopathologically inconclusive. A lateral thoracotomy with ideal tumorectomy was decided upon and carried out, and the diagnosis of plasma cell type Castleman disease was established.

This paper discusses the pathogenic mechanisms, symptoms, diagnosis and treatment of Castleman disease.

Key words: Castleman's disease, plasma cell type, mediastinal tumor.

 

Contact: Dr. Mihnea Davidescu, Str. Sfantul Elefterie Nr. 19, Sector 5, Bucuresti, E-mail: mihneadav@gmail.com 

 

Swyer James Syndrome: a case report

Maryam Hassanzad, Nazanin Parsanejad, Soheila Khalilzadeh
Swyer James Syndrome: a case report

Abstract

Swyer James syndrome is a rare condition clinically characterized by bronchiolitis and pneumonitis early in life.

A 2 year old girl referred to us with complaints of wheezing, chronic cough and fever since birth time. Based to her clinical symptoms and radiograph and CT scan findings, diagnosis of Swyer James syndrome was confirmed. She is under supportive treatment and her respiratory symptoms have been improved.

Key words: Swyer James syndrome, hyperlucency of the lung, bronchiolitis, pneumonitis

 

Contact:  Dr Nazanin Parsanejad, General Physician, Researcher of pediatric pulmonary diseases research center, NRITLD, Masih Daneshvari Hospital, Shaheed Beheshti University.   nazanin_in_n@yahoo.com
Pediatric ward, Masih Daneshvari Hospital, Darabad, Shahid Bahonar ave, Niavaran, Tehran, Iran